Primary Identifier | MGI:1339970 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 20168 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in endoplasmic reticulum tubular network formation. Is active in synapse. Is expressed in several structures, including genitourinary system; nervous system; olfactory epithelium; retina; and vibrissa. Used to study chronic kidney disease. Orthologous to human RTN3 (reticulon 3). PHENOTYPE: Mice homozygous for a null allele display age-related glomerulosclerosis and fibrosis with mitochondrial abnormalities and impaired renal function. [provided by MGI curators] |