| Primary Identifier | MGI:1346340 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 23942 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables histone deacetylase activity and transcription coregulator activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within genomic imprinting; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of NuRD complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and retina. Used to study systemic lupus erythematosus. Orthologous to human MTA2 (metastasis associated 1 family member 2). PHENOTYPE: Mice homozygous for a null allele exhibit partial embryonic and perinatal lethality, reduced weight, shortened lifespan, and increased susceptibility to systemic lupus erythematosus with increased T cell proliferation under Th2 conditions. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
