| Primary Identifier | MGI:102779 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 14156 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity; metal ion binding activity; and nuclease activity. Acts upstream of or within DNA repair and DNA replication. Predicted to be located in mitochondrion; nucleolus; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human FEN1 (flap structure-specific endonuclease 1). PHENOTYPE: Homozygous null mutants do not form an inner cell mass, lack DNA synthesis in blastocyst giant cells and die by embryonic day 9.5. Embryonic day 3.5 blastocysts are hypersensitive to irradiation. Heterozygotes show enhanced adenocarcinoma susceptibility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
