| Primary Identifier | MGI:2677061 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 269060 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables monoacylglycerol lipase activity. Involved in arachidonate metabolic process; regulation of neuroinflammatory response; and retrograde trans-synaptic signaling by endocannabinoid. Acts upstream of or within cannabinoid biosynthetic process; monoacylglycerol biosynthetic process; and neuroblast proliferation. Located in dendritic spine membrane and varicosity. Is active in postsynaptic membrane. Is expressed in brain and olfactory epithelium. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human DAGLA (diacylglycerol lipase alpha). PHENOTYPE: Mice homozygous for null mutations have decreased body weight, adult neuronal proliferation, and nervous system endocannaboid levels and abnormal inhibitory postsynaptic currents. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
