| Primary Identifier | MGI:1913322 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 66072 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Acts upstream of or within negative regulation of canonical Wnt signaling pathway; negative regulation of epithelial to mesenchymal transition; and protein dephosphorylation. Located in mitochondrion. Is expressed in 1-cell stage conceptus; blastocyst-stage conceptus; egg cylinder; and oocyte. Human ortholog(s) of this gene implicated in pheochromocytoma/paraganglioma syndrome 2. Orthologous to human SDHAF2 (succinate dehydrogenase complex assembly factor 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
