| Primary Identifier | MGI:106247 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 28000 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable identical protein binding activity and ubiquitin-ubiquitin ligase activity. Involved in proteasomal protein catabolic process. Acts upstream of or within several processes, including inner cell mass cell proliferation; positive regulation of astrocyte differentiation; and positive regulation of mRNA splicing, via spliceosome. Located in cytoplasm; lipid droplet; and nucleus. Is expressed in extraembryonic component and genitourinary system. Orthologous to human PRPF19 (pre-mRNA processing factor 19). PHENOTYPE: Mice homozygous for a null allele die prior to implantation and have defective cell proliferation. [provided by MGI curators] |