| Primary Identifier | MGI:97447 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 76303 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including phosphatidylinositol-4-phosphate binding activity; sterol binding activity; and sterol transfer activity. Predicted to be involved in several processes, including positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of secretory granule organization; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in several cellular components, including Golgi apparatus; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; immune system; liver; and retina nuclear layer. Orthologous to human OSBP (oxysterol binding protein). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality by E7.5. In vitro outgrowth assays show that blastocysts hatch from the zona pellucida but form irregular outgrowths with no inner cell mass colony or trophoblast giant cells after 3 days in culture. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
