| Primary Identifier | MGI:88439 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 12803 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable signaling receptor binding activity. Acts upstream of or within several processes, including negative regulation of photoreceptor cell differentiation; positive regulation of tyrosine phosphorylation of STAT protein; and regulation of retinal cell programmed cell death. Located in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Huntington's disease; disease of mental health; glaucoma; multiple sclerosis; and obesity. Orthologous to human CNTF (ciliary neurotrophic factor). PHENOTYPE: Mice homozygous for a disruption in this gene display progressive atrophy and degeneration of motor neurons in adulthood and reduced muscle strength. Another allele does not display any overt abnormalities at birth, however motor neuron sprouting does not occur after damage. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
