| Primary Identifier | MGI:104854 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 109910 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in activation of NF-kappaB-inducing kinase activity; protein K63-linked ubiquitination; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system and nervous system. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human ZFP91 (ZFP91 zinc finger protein, atypical E3 ubiquitin ligase). PHENOTYPE: T regulatory cell-specific deleted mice exhibit attenuated activation of autophagy in T regs and impaired T reg cell homeostasis and function resulting in increased sensitivity to colonic inflammation and inflammation-driven colon carcinogenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
