| Primary Identifier | MGI:104633 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 21888 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor binding activity; chromatin binding activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within Wnt signaling pathway and cellular response to leukemia inhibitory factor. Located in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; embryo mesenchyme; genitourinary system; and peripheral nervous system ganglion. Orthologous to human TLE4 (TLE family member 4, transcriptional corepressor). PHENOTYPE: Mice homozygous for a knock-out allele are runted and die around 4 weeks of age with leukocytopenia, B cell lymphopenia, reduced bone mineralization and reduced hematopoietic stem cell number and function. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
