Primary Identifier | MGI:95676 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 14537 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity. Involved in core 2 O-glycan biosynthetic process and positive regulation of leukocyte tethering or rolling. Acts upstream of or within kidney morphogenesis and tissue morphogenesis. Predicted to be located in Golgi cisterna; extracellular space; and trans-Golgi network. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human GCNT1 (glucosaminyl (N-acetyl) transferase 1). PHENOTYPE: Mice homozygous for disruptions in this allele display a grossly normal phenotype and are fertile. There are abnormalities in white blood cell counts and in inflammatory response however. [provided by MGI curators] |