| Primary Identifier | MGI:1353450 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 11668 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables 3-chloroallyl aldehyde dehydrogenase activity and aminobutyraldehyde dehydrogenase (NAD+) activity. Involved in fructose catabolic process; gamma-aminobutyric acid biosynthetic process; and negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including optic cup morphogenesis involved in camera-type eye development; positive regulation of apoptotic process; and retinoid metabolic process. Located in axon and synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ALDH1A1 (aldehyde dehydrogenase 1 family member A1). PHENOTYPE: Mice homozygous for a disruption in this gene show a significantly reduced ability to convert retinol to retinoic acid in the liver. Retinal morphology is normal even though the gene is normally highly expressed in the dorsal retina. Mice lacking both Aldh1a1 and Aldh1a2 exhibit azoospermia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
