| Primary Identifier | MGI:2385088 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 226026 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA secondary structure binding activity and single-stranded DNA binding activity. Acts upstream of or within several processes, including internal peptidyl-lysine acetylation; mitotic cell cycle phase transition; and protein localization to chromosome, centromeric region. Located in PML body; chromosome; and cytoplasm. Part of Smc5-Smc6 complex. Is expressed in ovary; secondary spermatocyte; and testis. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome. Orthologous to human SMC5 (structural maintenance of chromosomes 5). PHENOTYPE: Homozygous knockout in embryonic stem cells causes abnormal mitosis, increased apoptosis and a shift from pluripotency to differentiation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
