| Primary Identifier | MGI:2147707 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 107351 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable beta-catenin binding activity. Predicted to be involved in several processes, including negative regulation of cellular component organization; negative regulation of substrate adhesion-dependent cell spreading; and regulation of signal transduction. Predicted to be located in nucleus and ruffle membrane. Predicted to be active in cytoplasm and cytoskeleton. Is expressed in several structures, including central nervous system; craniocervical region bone; limb; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in spastic quadriplegic cerebral palsy 2. Orthologous to human KANK1 (KN motif and ankyrin repeat domains 1). PHENOTYPE: Mice homozygous for a null allele display decreased prepulse inhibition and abnormal eye anterior chamber depth. Mice with loss of expression in the kidney display increased susceptibility to chemical induced kidney injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
