Primary Identifier | MGI:2449470 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 240590 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables sequence-specific DNA binding activity. Acts upstream of or within several processes, including adult walking behavior; regulation of odontogenesis of dentin-containing tooth; and ventral spinal cord interneuron specification. Located in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and nose. Orthologous to human DMRT3 (doublesex and mab-3 related transcription factor 3). PHENOTYPE: Mice homozygous for a knock-out allele die from starvation at 2 months of age due to dental malocclusions; some males exhibit defects in sexual development. Mutant mice also exhibit locomotor abnormalities. Mice homozygous for a different knock-out allele exhibit decreased neocortex area. [provided by MGI curators] |