| Primary Identifier | MGI:1097717 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 107765 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables titin binding activity and transcription corepressor activity. Involved in cellular response to lipopolysaccharide and cellular response to xenobiotic stimulus. Acts upstream of or within phospholipase C/protein kinase C signal transduction; regulation of transcription by RNA polymerase II; and skeletal muscle cell differentiation. Located in I band and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; heart; male reproductive gland or organ; musculature; and somite. Human ortholog(s) of this gene implicated in congenital structural myopathy; dilated cardiomyopathy; hypertrophic cardiomyopathy; nemaline myopathy; and spinal muscular atrophy. Orthologous to human ANKRD1 (ankyrin repeat domain 1). PHENOTYPE: Mice homozygous for a null allele are viable, fertile, and show no apparent cardiac phenotype. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
