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Protein Coding Gene : Marchf5 membrane associated ring-CH-type finger 5
Primary Identifier  MGI:1915207 Organism  mouse, laboratory
Chromosome  19 NCBI Gene Number  69104
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable GTPase binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of mitochondrial fission; protein localization to mitochondrion; and protein ubiquitination. Predicted to be located in endoplasmic reticulum membrane and mitochondrion. Predicted to be active in mitochondrial outer membrane. Orthologous to human MARCHF5 (membrane associated ring-CH-type finger 5).
PHENOTYPE: Homozygous mutant knockout mice exhibit embryonic lethality. Heterozygous mutant mice exhibit defective immune responses to RNA viruses. [provided by MGI curators]
  • synonyms:
  • 2310008I22Rik,
  • Rnf153,
  • membrane-associated ring finger (C3HC4) 5,
  • RIKEN cDNA 1810015H18 gene,
  • Marchf5,
  • March5,
  • RIKEN cDNA E130202O05 gene,
  • 1810015H18Rik,
  • MGI:1916354,
  • RIKEN cDNA 2700055A20 gene,
  • MGI:1917884,
  • 5730499H23Rik,
  • MITOL,
  • 2700055A20Rik,
  • membrane associated ring-CH-type finger 5,
  • E130202O05Rik,
  • MGI:1917342,
  • MGI:6368853,
  • MGI:1925979,
  • RIKEN cDNA 5730499H23 gene,
  • ring finger protein 153,
  • MARCH-V,
  • RIKEN cDNA 2310008I22 gene
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