| Primary Identifier | MGI:97348 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 18089 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; mononuclear cell differentiation; and saliva secretion. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; skin; and submandibular gland primordium. Orthologous to human NKX2-3 (NK2 homeobox 3). PHENOTYPE: Homozygotes exhibit postnatal lethality due to acute intestinal malabsorption. Survivors recover well but exhibit splenic and Peyer's patch hypoplasia, intestinal villus malformation, gut truncation and distension, abnormal molar and sublingual gland development, and deranged lymphocyte homing. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
