| Primary Identifier | MGI:1352447 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 12780 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ABC-type transporter activity; bilirubin transmembrane transporter activity; and protein domain specific binding activity. Predicted to be involved in several processes, including carboxylic acid transport; intracellular chloride ion homeostasis; and mercury ion transport. Located in apical plasma membrane and intercellular canaliculus. Is expressed in foregut; genitourinary system; and liver and biliary system. Human ortholog(s) of this gene implicated in bile duct disease (multiple); bilirubin metabolic disorder (multiple); leukemia (multiple); liver disease (multiple); and lung non-small cell carcinoma. Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2). PHENOTYPE: Mice homozygous for disruptions in this gene have moderately enlarged livers, elevated plasma and urine bilirubin, and a reduced ability to clear various drugs and carcinogens from the blood. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
