| Primary Identifier | MGI:1099800 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 18034 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor activity. Involved in non-canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including follicular dendritic cell differentiation; germinal center formation; and spleen development. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; musculature; and thymus primordium. Used to study common variable immunodeficiency. Human ortholog(s) of this gene implicated in common variable immunodeficiency 10. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2). PHENOTYPE: Homozygotes for targeted null mutations exhibit gastric hyperplasia, enlarged lymph nodes, enhanced cytokine production by activated T cells, absence of Peyer's patches, increased susceptibility to Leishmania major, and early postnatal mortality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
