Primary Identifier | MGI:1918291 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 71041 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein domain specific binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of PcG protein complex. Is expressed in central nervous system; eye; limb; trunk somite; and urinary system. Orthologous to human PCGF6 (polycomb group ring finger 6). PHENOTYPE: Mice homozygous for a knock-out allele show early embryonic lethality associated with abnormal pre-implantation development, embryonic growth retardation, and defects in anterior-posterior axis specification and placental development. [provided by MGI curators] |