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Protein Coding Gene : Sh3pxd2a SH3 and PX domains 2A
Primary Identifier  MGI:1298393 Organism  mouse, laboratory
Chromosome  19 NCBI Gene Number  14218
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and protease binding activity. Involved in reactive oxygen species metabolic process. Acts upstream of or within in utero embryonic development. Located in cytoplasm and podosome. Is expressed in several structures, including brain; clavicle; liver; skeletal muscle; and spleen. Orthologous to human SH3PXD2A (SH3 and PX domains 2A).
PHENOTYPE: Homozygous disruption of this gene results in high neonatal lethality associated with a complete cleft of the secondary palate. [provided by MGI curators]
  • synonyms:
  • five SH3 domains,
  • SH3 and PX domains 2A,
  • expressed sequence AI256723,
  • MGI:1916883,
  • AA589508,
  • AI256723,
  • MGI:2147516,
  • Fish,
  • MGI:2147453,
  • predicted gene 5098,
  • 2310014D11Rik,
  • RIKEN cDNA 2310014D11 gene,
  • MGI:2147494,
  • expressed sequence AI413738,
  • MGI:3647497,
  • AI413738,
  • Sh3md1,
  • EG329070,
  • Gm5098,
  • SH3 multiple domains 1,
  • expressed sequence AA589508,
  • Tks5,
  • Sh3pxd2a,
  • predicted gene, EG329070
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