Primary Identifier | MGI:103241 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 20874 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable histone kinase activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in regulation of cell migration. Located in cell leading edge. Is expressed in several structures, including alimentary system; genitourinary system; musculature; nervous system; and sensory organ. Orthologous to human SLK (STE20 like kinase). PHENOTYPE: Mice homozygous for a gene trapped allele die by E14.5, exhibiting severe developmental defects, impaired neuronal and skeletal muscle development, abnormal placental differentiation and vascularization, and increased apoptosis. [provided by MGI curators] |