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Protein Coding Gene : Cfap58 cilia and flagella associated protein 58
Primary Identifier  MGI:2685815 Organism  mouse, laboratory
Chromosome  19 NCBI Gene Number  381229
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Involved in Notch signaling pathway and sperm flagellum assembly. Acts upstream of or within sperm axoneme assembly. Located in centrosome and sperm midpiece. Used to study oligoasthenoteratozoospermia. Human ortholog(s) of this gene implicated in spermatogenic failure 49. Orthologous to human CFAP58 (cilia and flagella associated protein 58).
PHENOTYPE: Homozygous knockout affects spermatogenesis and leads to male infertility. [provided by MGI curators]
  • synonyms:
  • LOC381229,
  • gene model 969, (NCBI),
  • Gm969,
  • Cfap58,
  • coiled-coil domain containing 147,
  • cilia and flagella associated protein 58,
  • Ccdc147
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