| Primary Identifier | MGI:96572 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 16333 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including identical protein binding activity; signaling receptor activator activity; and signaling receptor binding activity. Involved in insulin receptor signaling pathway. Acts upstream of with a positive effect on receptor internalization. Located in cytosol. Is active in extracellular space. Is expressed in several structures, including gut; liver; trunk; and yolk sac. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to human INS (insulin). PHENOTYPE: Mice homozygous for disruptions in this gene have a somewhat increased pancreatic beta cell mass and a limited amount of hyperplasia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
