Primary Identifier | MGI:109574 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 21684 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) An extracellular matrix structural constituent. Predicted to act upstream of or within sensory perception of sound. Located in extracellular matrix. Is expressed in inner ear. Orthologous to human TECTB (tectorin beta). PHENOTYPE: Homozygotes for a null allele show an enlarged tectorial membrane with a disrupted striated-sheet matrix, absence of the marginal band, and low-frequency hearing loss. However, basilar-membrane and neural tuning are both enhanced in high-frequency cochlear regions, with little loss in sensitivity. [provided by MGI curators] |