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Protein Coding Gene : Dclre1a DNA cross-link repair 1A
Primary Identifier  MGI:1930042 Organism  mouse, laboratory
Chromosome  19 NCBI Gene Number  55947
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable 5'-3' DNA exonuclease activity; beta-lactamase activity; and damaged DNA binding activity. Acts upstream of or within nucleotide-excision repair. Predicted to be located in fibrillar center and nucleoplasm. Orthologous to human DCLRE1A (DNA cross-link repair 1A).
PHENOTYPE: Mice homozygous for a targeted null mutation are viable and fertile but exhibit increased sensitivity to the DNA interstrand cross-linking agent mitomycin C. [provided by MGI curators]
  • synonyms:
  • DNA cross-link repair 1A,
  • AU022226,
  • RIKEN cDNA 2810043H12 gene,
  • SNM1,
  • expressed sequence AU022226,
  • MGI:1919930,
  • mSNM1,
  • 2810043H12Rik,
  • SMN1a,
  • MGI:2147649,
  • Dclre1a
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