Primary Identifier | MGI:1920692 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 73442 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ATP binding activity. Predicted to be located in cytoplasm and nucleus. Is expressed in nervous system; retina; and white fat. Orthologous to human HSPA12A (heat shock protein family A (Hsp70) member 12A). PHENOTYPE: Homozygous knockout affects glucose metabolism, reducing susceptibility to diet-induced obesity. It also reduces diet-induced damage to the liver through suppression of macrophage recruitment, increases LPS-induced liver damage and increases susceptibility to ischemic brain injury. [provided by MGI curators] |