Primary Identifier | MGI:109161 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 14773 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable beta-adrenergic receptor kinase activity and protein serine/threonine kinase activity. Involved in fat cell differentiation. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human GRK5 (G protein-coupled receptor kinase 5). PHENOTYPE: Homozygous mutation of this gene results in a decrease in thermal pain sensation. Mice homozygous for a knock-out allele exhibit decreased response of heart to induced stress. [provided by MGI curators] |