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Protein Coding Gene : Cdnf cerebral dopamine neurotrophic factor
Primary Identifier  MGI:3606576 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  227526
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable growth factor activity. Predicted to be involved in dopaminergic neuron differentiation and neuron projection development. Predicted to be located in extracellular region. Predicted to be active in endoplasmic reticulum and extracellular space. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; salivary gland; and skeletal muscle tissue. Orthologous to human CDNF (cerebral dopamine neurotrophic factor).
PHENOTYPE: Mice homozygous for a null allele exhibit degeneration of enteric neurons, age-dependent enhanced amphetamine-induced hyperlocomotion, and altered dopamine neuronal function. [provided by MGI curators]
  • synonyms:
  • Armetl1,
  • cerebral dopamine neurotrophic factor,
  • Cdnf,
  • arginine-rich, mutated in early stage tumors-like 1
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