| Primary Identifier | MGI:1923580 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 109079 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein heterodimerization activity; protein homodimerization activity; and selenide, water dikinase activity. Predicted to be involved in selenocysteine biosynthetic process. Predicted to be located in nuclear membrane and plasma membrane. Predicted to be active in cytoplasm. Is expressed in central nervous system; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human SEPHS1 (selenophosphate synthetase 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic growth retardation and complete lethality by E14.5 with failure of the amnion to separate from the yolk sac. Mice homozygous for a conditional allele activated in the liver exhibit reduced liver iron and manganese levels. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
