Primary Identifier | MGI:1915777 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 68527 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable BMP binding activity. Involved in negative regulation of SMAD protein signal transduction. Acts upstream of or within negative regulation of osteoblast differentiation. Located in cytoplasm and extracellular matrix. Is expressed in several structures, including cerebral cortex; limb; and skeleton. Orthologous to human UCMA (upper zone of growth plate and cartilage matrix associated). PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal skeleton phenotype. [provided by MGI curators] |