Primary Identifier | MGI:1917274 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 70024 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables enzyme binding activity. Acts upstream of or within cell population proliferation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nuclear replication fork. Is expressed in several structures, including adrenal gland; brain; gonad; gut; and immune system. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MCM10 (minichromosome maintenance 10 replication initiation factor). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced embryonic cell proliferation and early embryonic letahlity. [provided by MGI curators] |