| Primary Identifier | MGI:1925751 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 209378 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in hyaluronan metabolic process. Located in collagen-containing extracellular matrix. Is expressed in several structures, including genitourinary system; gut; limb segment; meninges; and sensory organ. Orthologous to human ITIH5 (inter-alpha-trypsin inhibitor heavy chain 5). PHENOTYPE: Mice homozygous for a null allele exhibit thin skin with thinner epidermis and stratum corneum and decreased keratinocyte proliferation in culture. Mice show increased adipose tissue mass, with increased proliferation and adipogenic differentiation of adipose stem cells that are more responsive to stimulation with inflammatory mediators. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
