| Primary Identifier | MGI:1329014 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 20844 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ubiquitin-like protein ligase binding activity. Predicted to be involved in positive regulation of exosomal secretion; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; and regulation of extracellular exosome assembly. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of ESCRT-0 complex. Is expressed in dorsal root ganglion; future spinal cord; hippocampus; sciatic nerve; and spinal cord. Orthologous to human STAM (signal transducing adaptor molecule). PHENOTYPE: Mice homozygous for a targeted null mutation exhibit progressive growth retardation, priapism, male infertility, degeneration of hippocapal CA3 pyramidal neurons and premature death, but exhibit normal lymphocyte development, proliferation and responses. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
