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Protein Coding Gene : Nebl nebulette
Primary Identifier  MGI:1921353 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  74103
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable actin filament binding activity; filamin binding activity; and tropomyosin binding activity. Predicted to be involved in cardiac muscle thin filament assembly. Predicted to be located in Z disc and stress fiber. Is expressed in several structures, including brain; genitourinary system; heart; periderm; and skeletal muscle. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human NEBL (nebulette).
PHENOTYPE: Mice homozygous for a null allele exhibit decreased exercise tolerance and increased response of heart to exercise. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA A630080F05 gene,
  • 1200007O21Rik,
  • A630080F05Rik,
  • RIKEN cDNA 1200007O21 gene,
  • expressed sequence BB140644,
  • nebulette,
  • MGI:3041201,
  • RIKEN cDNA D830029A09 gene,
  • Lnebl,
  • MGI:2139435,
  • D830029A09Rik,
  • Nebl,
  • MGI:2443546,
  • BB140644
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