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Protein Coding Gene : Nrarp Notch-regulated ankyrin repeat protein

Primary Identifier  MGI:1914372 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  67122
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable chloroplast targeting sequence binding activity. Acts upstream of or within several processes, including angiogenesis; positive regulation of vascular endothelial cell proliferation; and somite rostral/caudal axis specification. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mesenchyme; genitourinary system; and retina. Orthologous to human NRARP (NOTCH regulated ankyrin repeat protein).
PHENOTYPE: Mice homozygous for a null allele exhibit delayed retinal vascularization due to increased vascular regression. Mice homozygous for a different knock-out allele exhibit vertebral and rib fusions. [provided by MGI curators]
  • synonyms:
  • 2700054M22Rik,
  • Nrarp,
  • Notch-regulated ankyrin repeat protein,
  • RIKEN cDNA 2700054M22 gene

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