Primary Identifier | MGI:1931035 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 58202 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA binding activity. Involved in several processes, including negative regulation of stem cell differentiation; negative regulation of transcription elongation by RNA polymerase II; and stem cell differentiation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of NELF complex. Is expressed in several structures, including blastocyst; early embryo; and gonad. Orthologous to human NELFB (negative elongation factor complex member B). PHENOTYPE: Mice homozygous for a knock-out allele fail to develop inner cell masses and die between E5 and E13.5. [provided by MGI curators] |