| Primary Identifier | MGI:102673 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 16871 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables transcription cis-regulatory region binding activity and transcription coactivator binding activity. Involved in positive regulation of DNA-templated transcription. Acts upstream of or within several processes, including nervous system development; placenta development; and positive regulation of transcription by RNA polymerase II. Located in chromatin. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study hypopituitarism. Human ortholog(s) of this gene implicated in combined pituitary hormone deficiency. Orthologous to human LHX3 (LIM homeobox 3). PHENOTYPE: Homozygotes for a targeted null mutation exhibit failure of growth and differentiation of Rathke's pouch, lack both anterior and intermediate lobes of the pituitary gland, and die perinatally, within 24 hours of birth. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
