Primary Identifier | MGI:98445 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 20932 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables COPII receptor activity. Involved in COPII-coated vesicle cargo loading; lipid export from cell; and lipoprotein transport. Predicted to be located in Golgi apparatus; cytosol; and nuclear membrane. Predicted to be active in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum exit site; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in embryo and pancreas tip epithelium. Orthologous to human SURF4 (surfeit 4). PHENOTYPE: Mice die between E3.5 and E9.5. Mice homozygous for a conditional allele activated in the liver exhibit reduced circulating cholesterol and triglyceride levels. [provided by MGI curators] |