| Primary Identifier | MGI:102718 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 22325 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables epidermal growth factor receptor binding activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including lamellipodium assembly; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and small GTPase-mediated signal transduction. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human VAV2 (vav guanine nucleotide exchange factor 2). PHENOTYPE: Homozygous null mutants have defects in humoral immune response to type II thymus-independent antigens, in primary response to thymus-dependent antigens and inability to switch immunoglobulin class, form germinal centers and generate secondary responses. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
