Primary Identifier | MGI:1860437 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 56177 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in neuronal signal transduction and regulation of axon extension. Located in several cellular components, including axonal growth cone; neuronal cell body; and synaptic membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Is expressed in several structures, including central nervous system; embryo ectoderm; peripheral nervous system ganglion; sensory organ; and tooth. Orthologous to human OLFM1 (olfactomedin 1). PHENOTYPE: Mice homozygous for a null mutation display reduced cerebral infarction size in males, decreased body weight and defects in embryo implantation, mating activity and ovulation in females, and reduced female fertility most likely as a secondary effect of impaired olfaction. [provided by MGI curators] |