Primary Identifier | MGI:107485 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 19730 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in brush border; cytosol; and nucleus. Predicted to be active in plasma membrane. Is expressed in several structures, including blastocyst; early embryo; nervous system; ovary; and retina. Orthologous to human RALGDS (ral guanine nucleotide dissociation stimulator). PHENOTYPE: Homozygous mutant mice exhibit reduced tumor incidence, size and progression to malignancy in multistage skin carcinogenesis. [provided by MGI curators] |