| Primary Identifier | MGI:87859 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 11350 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including ATP binding activity; metal ion binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of long-term synaptic potentiation; positive regulation of cell migration; and regulation of T cell activation. Acts upstream of or within several processes, including cell surface receptor signaling pathway; lymphocyte differentiation; and regulation of signal transduction. Located in several cellular components, including actin cytoskeleton; cell leading edge; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple) and leukemia (multiple). Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase). PHENOTYPE: Mice homozygous for targeted mutations that inactivate the gene have increased perinatal and postnatal mortality and may display foreshortened crania, abnormal development of spleen, head, heart and eye, reduced B and T cell populations, and osteoporosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
