Primary Identifier | MGI:2138935 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 98952 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in positive regulation of osteoclast differentiation. Located in cytoplasm; membrane raft; and nucleus. Is expressed in craniocervical region bone; heart ventricle; submandibular gland primordium; and thoracic segment skeleton. Orthologous to human EEIG1 (estrogen-induced osteoclastogenesis regulator 1). PHENOTYPE: Homozygous knockout reduces susceptibility to inflammation-induced bone resorption by suppressing osteoclast formation. [provided by MGI curators] |