Primary Identifier | MGI:1921266 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 74016 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables methylated histone binding activity. Involved in negative regulation of macromolecule biosynthetic process; stem cell differentiation; and stem cell population maintenance. Part of ESC/E(Z) complex. Is expressed in several structures, including brain ventricular layer; cerebral cortex subventricular zone; early conceptus; genitourinary system; and intestine. Orthologous to human PHF19 (PHD finger protein 19). PHENOTYPE: Mice homozygous for a null allele exhibit an extra rib, enlarged spleen in aged mice and long-term aberrant hematopoiesis. [provided by MGI curators] |