| Primary Identifier | MGI:1916851 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 69601 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein kinase binding activity. Involved in several processes, including cellular response to cytokine stimulus; neurogenesis; and regulation of signal transduction. Located in axon; cytoplasm; and neuronal cell body membrane. Part of AIP1-IRE1 complex. Is expressed in cartilage; telencephalon; and trigeminal ganglion. Human ortholog(s) of this gene implicated in artery disease (multiple); lung cancer; prostate cancer; and stomach cancer. Orthologous to human DAB2IP (DAB2 interacting protein). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired IRE1-mediated endoplasmic reticulum (ER) stress-induced responses. Mice homozygous for a gene trap allele exhibit delayed Purkinje cell dendritogenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
