Primary Identifier | MGI:1306803 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 16874 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within forebrain development and neuron maturation. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; forebrain; genitourinary system; and sensory organ. Orthologous to human LHX6 (LIM homeobox 6). PHENOTYPE: Homozygous mutation of this gene results in impaired migration and specification of cortical interneurons, postnatal lethality and weakness. [provided by MGI curators] |