| Primary Identifier | MGI:97797 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 19224 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen and prostaglandin-endoperoxide synthase activity. Acts upstream of or within prostaglandin biosynthetic process; regulation of blood pressure; and regulation of cell population proliferation. Located in cytoplasm and photoreceptor outer segment. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Used to study pre-eclampsia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human PTGS1 (prostaglandin-endoperoxide synthase 1). PHENOTYPE: Null mutants show impaired platelet aggregation, reduced inflammatory responses, and diminished susceptibility to induced papillomas. Female mutants exhibit delayed parturition and their offspring die neonatally. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
