| Primary Identifier | MGI:2442794 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 227801 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including SH3 domain binding activity; guanyl-nucleotide exchange factor activity; and phosphatidylinositol-3-phosphate binding activity. Involved in endocytic recycling and positive regulation of GTPase activity. Acts upstream of or within synaptic vesicle endocytosis. Located in several cellular components, including clathrin-coated vesicle membrane; dendrite; and neuronal cell body. Is expressed in brain; branchial arch; embryo; forelimb bud; and future forebrain. Orthologous to human DENND1A (DENN domain containing 1A). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality during organogenesis, small brain size due to reduced proliferation, delayed PGC migration, and impaired hepatic cell proliferation, the differentiation of hepatocyte, and hepatic hematopoiesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
